Prevalence of thrombocytosis in epidermolysis bullosa patients

Document Type : Brief Communications Arising and Corrections

Authors

1 cairo, egypt

2 zoology Department, Faculty of Science, Beni Suef University

3 Hail, faculty of Science

4 Zoology Department, Faculty of Science, Hail Univ., Saudi Arabia

5 Hail

Abstract

Epidermolysis bullosa (EB) is a rare inherited genetic disease characterized by extreme fragility of the skin and mucous membranes, which gives rise to the formation of blisters and ulcers following minor trauma. As EB is a rare disease, the reported studies regarding epidermolysis bullosa are very limited. This study was aimed to investigate the alterations in the hematologic parameters and assess the prevalence of thrombocytosis in children suffering from EB. Eight EB patients aged (3 to 12 years) from the Dermatology Unit of King Khalid Hospital (KKH), Hail city, Saudi Arabia were included in this study.
The hematological changes of EB patients were characterized by a significant decrease in the total erythrocytes (RBCs) count, hemoglobin (Hb), hematocrits (PCV) percentage, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH). The predominance of thrombocytosis and lymphocyte production was verified in this study. Moreover, Staphylococcus aureus and Streptococcus epidermidis were the most isolated microorganisms from wound cultures of EB patients. In conclusion, thrombocytosis, anemia, and/or poor nutritional status seem to be common complications in nearly all cases of EB.

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