Document Type : Original Article
Authors
1
Therapeutic Chemistry Department, Pharmaceutical and Drug Industries Institute, National Research Centre (NRC), Giza, Egypt
2
Prof. of Biochemistry at Department of Therapeutic Chemistry, National Research Centre
3
Pharmacology Department, National Research Centre, Giza, Egypt
4
Al-Azhar University
5
Molecular Biology, Zoology and Entomology Department, Faculty of Science, Al-Azhar University, 11754 Nasr City, Cairo, Egypt.
Abstract
Autistic spectrum disorders (ASD) are neurodevelopmental disorders that affect behavior, communication, and social interaction. Over the past three decades, the prevalence of autism has increased at an alarming rate, though it varies by country. The present study aimed to evaluate the therapeutic benefits of vitamin E and. Omega-3 against propionic acid (PPA) induced autism in the rodent model. Forty male Wistar albino juvenile rats were divided equally into 5 groups. Group 1: received saline and served as control. Group 2: orally administered PPA at a dose of 250 mg /kg bw/day for 3 days and served as a positive control. Group 3: given PPA with vitamin E. Group 4: given PPA with omega-3. Group 5: given PPA along with vitamin E and omega-3. Behavioral patterns were observed, and oxidative stress-related markers were determined. Moreover, serotonin, dopamine, gamma-aminobutyric acid (GABA), glutamate, interleukins (IL-6 and IL-10), in addition to brain phospholipid profile as phosphatidylethanolamine (PE), phosphatidylserine (PS) and phosphatidylcholine (PC) were measured. Acetylcholinesterase (AchE) and propionyl-CoA carboxylase (PCCA) activity were evaluated across all groups. PPA administration significantly reduced social performance, IL-10, dopamine, GABA, oxidative stress biomarkers, and phospholipid profile levels. It also increased IL-6, serotonin, and glutamate. Vitamin E and omega-3 supplementation showed potential in managing ASD by counteracting PPA-induced autistic features through their antioxidant and anti-inflammatory properties. In conclusion, our research suggests that vitamin E and omega-3 can counteract PPA-induced autistic features, highlighting their potential as therapeutic agents for ASD management.
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